How PATs Improve Bioreactor Performance And Inline Monitoring

Accurately monitoring process parameters and bioreactor performance attributes using inline sensors is an important step in optimizing biomanufacturing processes. Leveraging real-time feedback to control important elements such as the supply of oxygen and air, the agitation number, and pH can help improve cell growth, productivity, and product quality.

One of the best ways to achieve success with inline monitoring is by implementing process analytical technologies (PAT) for measuring bioreactor and bioprocessing performance. Data received from sensors and CFD modeling can improve bioreactor performance. Developing processes that leverage PAT tools can lead to strong improvements in productivity, quality, and process stability. In this Q&A, Sr. R&D Scientist Shunsuke Shiina reviews the role of PATs in improving manufacturing processes as well as the challenges presented by new sensors and PAT tools.