Newsletter | October 24, 2024

10.24.24 -- How Elixirgen Manufactures Hematopoietic Stem Cells At The Bedside

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Strategies for the Separation and Analysis of Empty and Filled Capsids During Viral Vector Production

There are challenges in AAV empty-full separation in the gene therapy industry as well as some misconceptions. Experts are always looking for ways to find the best solution to these challenges. Discover the strategies of AAV capture and empty-full separation, as well as the trends driving innovation in this area. Learn more here.

FOCUS ON MANUFACTURING

How Elixirgen Manufactures Hematopoietic Stem Cells At The Bedside

The company uses a mobile manufacturing system to produce autologous stem cell therapy for patients with dyskeratosis congenita and other telomere biology disorders.

Biopharma's Talent Crunch: How To Gain And Retain Skilled Labor

What strategies should your company consider for recruiting, training, and retaining qualified candidates in order to remain competitive in a burgeoning biopharma market?

Addressing The Challenges In Lentivirus Harvest Clarification

Traditional depth filtration struggles with lentiviral harvest clarification, leading to low yields and high costs. However, single-use centrifugation offers a promising alternative.

Identity Testing By NGS: Risk Mitigation For Viral Gene Therapies

This presentation explores regulatory requirements for identity testing, compares NGS applications for identity testing to traditional methods, and describes the impact of not establishing a testing strategy.

Systematic Approach to Enhancing iPSC Expansion

Learn how stirred-tank bioreactors can optimize hiPSC cultures, achieving over 10× higher cell density while retaining viability — ideal for drug discovery, disease modeling, and regenerative therapies.

Comparing Analytical Approaches For AAV Characterization

Review evidence that proves mass photometry is a favorable method due to its accuracy, versatility, and low time, sample, and expertise requirements.

The Key Role Of Downstream Processing In RNA-LNP Drug Development

Explore the crucial aspects of lipid nanoparticle (LNP) development, including the essential downstream processes of Tangential Flow Filtration (TFF) and normal flow filtration.

Adapting A rcAAV Assay For Commercial Manufacturing

Better understand the intricacies of AAV triple transfection and how advances in vector production and cell line optimization are enhancing gene therapy.

How Custom Media And Buffers Support CGT Development

In this presentation, experts emphasize the significance of optimized cell media and buffers in the production of cell and gene therapy products.

Leverage qPCR And dPCR To Streamline Biologics Development

PCR methods that deliver high-quality results throughout biologics development and biomanufacturing can help biologics manufacturers bridge the gap from basic research to clinical trials and manufacturing.

Standardization Of Flow Cytometry In Cell And Gene Therapy

Watch to learn about solutions to address challenges in standardizing flow cytometry and cell analysis solutions that support drug development at every stage.

InSiliCHO: Modeling Cell Line Dynamics For Process Development

Modeling and simulation can be a powerful tool for bioprocess design. Find out how you can utilize an open source implementation for in silico simulation of CHO.

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MANUFACTURING SOLUTIONS

High-Performance Delivery Of Molecules With Minimal Disturbance - MaxCyte, Inc.

Configurable Assemblies: Customized For Specific Bioprocess Needs - Corning Life Sciences

An Introduction To The Sepax C-Pro Cell Processing System - Cytiva

Innovations In Transfection And Electroporation - Lonza

SpectraComp® Unmixing Controls Demo - Slingshot Biosciences, Inc.

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It's no secret that on-going research aims to improve the efficacy and specificity of non-viral approaches for genetic engineering. But the field is rapidly evolving with research aimed at improving transfection efficiency, targeting, and safety profiles of non-viral delivery systems. Join Cell & Gene Live to discuss the most notable approaches and recent breakthroughs as well as promising non-viral vectors used in clinical trials. Attendance is free thanks to the support of MaxCyte.

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