High-Content Flow Cytometry: Spectral and Conventional Services

Flow cytometry is a foundational tool in modern drug development, and its application in receptor occupancy (RO) assays has become essential for evaluating therapeutic engagement with disease targets. Precision for Medicine leverages both conventional and spectral flow cytometry platforms to deliver high-content, customizable assays that quantify drug-receptor interactions in a cell-specific, high-resolution format. These RO assays are critical across all stages of development. Three primary RO assay formats are available: free receptor assays (measuring unbound receptors), total receptor assays (capturing all receptor expression regardless of binding state), and direct assessments of bound drug (measuring therapeutic-antibody-bound receptors using anti-drug antibodies). Each format is tailored to the drug’s mechanism of action and trial needs, ensuring meaningful insights into efficacy, safety, and dosing strategies.

Precision's validated and standardized global laboratory infrastructure ensures harmonized sample testing, including CLIA-compliant assays for patient selection. Real-time whole blood assays and stabilized sample processing support operational flexibility, while the integration of advanced cytometers allows deep cellular analysis. By combining technical expertise, regulatory alignment, and operational scalability, Precision for Medicine enables sponsors to de-risk development and make informed decisions based on real-time receptor engagement data.