Newsletter | August 5, 2025

08.05.25 -- Here's What Limits AI's Outlook For Replacing Knowledge Workers

SPONSOR

Webinar: Unlock Viral Vector Yield and Efficiency with Upstream Intensification

Discover how Repligen's TFDF technology is changing viral vector manufacturing. In this webinar, you’ll learn how high-density, perfusion-based production using HEK293 cells and ready-to-use plasmids can boost AAV and LVV yields by up to 30 times—while keeping quality high. See how this efficient, scalable process helps lower costs and speed up access to life-changing gene therapies and vaccines. Click here to learn more.

FOCUS ON MANUFACTURING

Here's What Limits AI's Outlook For Replacing Knowledge Workers

Even after AI developers clean up hallucinations and other short-term issues, a large-scale workforce replacement faces a few intractable obstacles.

Addressing The Challenges In Lentivirus Harvest Clarification

Traditional depth filtration struggles with lentiviral harvest clarification, leading to low yields and high costs. However, single-use centrifugation offers a promising alternative.

A Holistic Approach To Process Scale-Up

Explore an innovative concept that optimizes USP and DSP processes, as well as discover scale-up results and a fully automated and integrative DSP system.

Digital Biomanufacturing, Now: From Digital Dreamer To Digital Doer

Discover how digital biomanufacturing is revolutionizing drug production by exploring strategies for integrating digital technologies to enhance efficiency and innovation in bioprocessing workflows.

Why Downstream Processing Is Crucial In RNA-LNP Drug Development

Explore the key aspects of lipid nanoparticle (LNP) development, including the essential downstream processes of Tangential Flow Filtration (TFF) and normal flow filtration.

Amino Acid Analysis Indicates Metabolic Differences In MCB CAR T-Cells

How do the metabolic differences in CAR T-cells activated with multi-cytokine backpacks (MCBs) reveal correlations between CAR T-cell activation, nutrient metabolism, and efficacy?

The Importance Of Scalability In Viral Vectors

Diseases that lack a cure, or even treatment, may be addressed with new gene therapeutic classes. This potential has spurred new investments in the drug development and commercialization space.

Embarking On A Successful Cleanroom Project: Conception To Delivery

Learn how you can obtain comprehensive solutions for cleanroom projects that help you ensure regulatory compliance and operational efficiency.

Sterility Testing: Isolator Solutions To Minimize Contamination Risk

Sterility testing is susceptible to contamination, resulting in costly false positives, batch failures, and production delays. Isolator technology offers a robust solution to mitigate these challenges.

Why Cell Washing Is The Hidden Bottleneck In Gene-Edited Cell Therapy

Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

Customizable DMSO-Free Cryopreservation Media Formulation

Cryopreservation enables cell therapy by storing cells long-term. A DMSO-free formula preserves cell viability and health, minimizing toxicities linked with traditional cryoprotectants.

SPONSOR

Webinar: A Case Study for Viral Vector Process Impurity Profile: Evaluation of EndoCleave

Join us for a deep dive into the performance of Roche’s DNA endonuclease, EndoCleave, in AAV and LVV production. This webinar compares EndoCleave to other enzymes across key parameters—concentration, temperature, incubation time, and salt levels—using a HEK293 TTx platform, revealing insights to improve viral vector purity, safety, and scalability in gene therapy manufacturing. Click here to learn more.

MANUFACTURING SOLUTIONS

Maintaining Cell Viability During The Cryovial Filling Process - 3P innovation

Vertical-Wheel Bioreactor: PBS-15 - PBS Biotech, Inc.

Lipid Nanoparticle (LNP) Production Systems - KNAUER

RoosterReplenish™ hMSC Bioreactor Feed - RoosterBio

Precision Filtration With Unmatched Control And Seamless Validation - Cytiva

Contamination Control Products For Cell and Gene Therapy - Contec, Inc.

SPONSOR

Webinar: Scaling Plasmid DNA Production: A Proven Strategy for Higher Yields

With rising demand for plasmid DNA in gene therapies and vaccines, this Thermo Fisher webinar explores how Akron Bio leveraged Gibco™ Bacto™ CD Supreme FPM and peptones to boost productivity. Learn how media and peptone selection, process optimization, and scalable solutions are transforming pDNA development. Gain actionable insights to improve yield and efficiency. Click here to learn more.

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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