Gammaretrovirus: Overcoming Development And Manufacturing Challenges

By Pratima Cherukuri, Genezen

As an effective tool for gene delivery, gammaretrovirus (also referred to as retrovirus) has played an integral part in the rapid advancement of cell and gene therapies. In such a new therapeutic space, understanding the intricacies of gammaretroviral vector (RV) development and manufacturing – from pseudotyping and upstream processing (USP) to downstream processing (DSP) and the final fill – is a significant challenge. In this white paper, we delve into the key factors that developers must consider to ensure the success of their RV project.