Four Obstacles In Cell And Gene Therapy Development

By Vanee Pho-Conners, Director of Product, Mission Bio

Cell and gene therapies, while miraculous, are incredibly complex and require much more rigorous manufacturing and analytical testing than traditional biologics/large molecule drugs. Safety concerns have plagued the field from its inception and developing today’s therapies contains a multitude of challenges, which could ultimately lead to failed drug development and fewer treatments available to patients who desperately require them.

With new innovative single-cell technologies, it is now possible to measure multiple cell characteristics, such as DNA sequence and protein expression, simultaneously within the same cells. Such advancements have the potential to greatly improve the analytical characterization of cell and gene therapies, in terms of time, simplicity, and sensitivity.

In this blog post, we explore some of the major challenges in the cell and gene therapy world and how single-cell multi-omics analysis can overcome many of these issues.