Evaluating The Automated Accellix® Platform Against Conventional Flow Cytometry For Cell Therapy Samples

By Sanika Gad, Senior Associate Scientist, Analytical Development

Evaluate an automated, microfluidic cartridge‑based flow cytometry workflow against conventional lab‑based methods for cell‑therapy quality control across representative sample types: incoming starting material, in‑process activated cells, and final drug product. Using off‑the‑shelf assay panels, the automated system aimed to streamline immunophenotyping inside the manufacturing environment, reducing labor and expertise requirements while accelerating decision‑making. Reported results indicate data quality comparable to traditional flow cytometry, with well‑resolved populations and appropriate controls enabling standardization and method validation. Crucially, the automated approach offers markedly faster turnaround times and simplified operation, addressing persistent bottlenecks in manufacturing QC. The poster’s placement at an industry conference underscores ongoing efforts to integrate on‑site, rapid immunophenotyping into end‑to‑end cell‑therapy workflows, helping improve reproducibility, scalability, and cost‑efficiency of analytical testing in GMP contexts.