Entegris Cell & Gene Tech Expo April 2026: Cell Therapy

Maintaining the integrity of a closed system while managing high solid content is a persistent challenge in modern bioprocessing, particularly as adherent cell lines scale up. Traditional clarification and separation methods often introduce significant mechanical stress or require complex, expensive hardware that is difficult to pivot between research and GMP environments. Size-exclusion technology utilizing surgical-grade mesh offers a streamlined alternative, providing a chemically inert and customizable solution for retaining microcarriers, removing aggregates, or reducing visible particulates.

By integrating these flexible mesh bags into single-use manifolds, manufacturers can implement coarse clarification steps that protect downstream depth filters and chromatography resins from premature fouling. This approach supports a continuous workflow that is easily driven by standard peristaltic pumps or even gravity for ultra-gentle handling. Technical data confirms that these systems meet stringent particulate standards while ensuring high yields, offering a cost-effective path to process robustness. Explore how tailored mesh portfolios bridge the gap from benchtop proof-of-concept to commercial-scale manufacturing.

About Entegris

Entegris is in a unique position to help overcome cold temperature challenges by offering assemblies designed for extreme cold and by partnering with qualified equipment manufacturers specializing in reliable, cold-chain containment. Let us help you gain control over your processes and reduce the potentially enormous financial risk to your valuable products.