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Cell and gene therapies are gaining traction as alternative treatments for various diseases, resulting in metabolite analysis becoming increasingly important in regenerative medicine. Learn more about the importance of understanding and optimizing cell culture media formulations and enhancing the effectiveness of CAR-T cell therapy.
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T cells are lymphocytes that have special cell surface receptors that recognize antigens. Chemically-defined media provides improved batch-to-batch results and removes some regulatory concerns since it excludes serum products; however, serum-free media may yield lower CAR-T efficacies. Read more to understand how to optimize your media.
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This experiment tests two distinct bioreactor runs, with one implementing the use of an on-line, biosensor-based device with real-time measurements. The results demonstrate that continuous real-time monitoring of glucose and lactate paired with dynamic glucose feed control leads to improved process and product parameters.
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With an in-line, Raman-based PAT solution, you can monitor and control several critical process parameters (CPP) to maintain optimal cell culture conditions. Review the results when this tool was tested on CHO and HEK293 cell lines, showing a strong correlation between biomass units and total cell densities.
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