Article | February 21, 2020

Enhanced Host Cell Protein Analysis In Biologics Manufacturing

Source: Cytiva
protein molecule

During biologic manufacturing, it’s common to use host cells to express a target biological molecule as a final drug product, or a part of the final drug product. The host cell continues to produce its own biological molecules together with the drug product. These host cell-derived biological molecules are regarded as impurities and are subject to target substances to be removed during downstream purification. One of the main impurities are host cell-derived proteins, known as Host Cell Proteins (HCPs). The level of host cell proteins in biologics must be monitored carefully during development to optimize the downstream purification, as well as at final production to ensure the quality, efficacy and safety of the biological drugs.

The most widely used and accepted method to monitor host cell protein levels in biologics is an immunological assay, Enzyme-Linked Immunosorbent Assay, also known as ELISA. However, this coverage assay comes with some known challenges. Learn more about an enhanced anti-host cell protein antibody coverage analysis method solution.

VIEW THE ARTICLE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of Cell & Gene? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: