Newsletter | April 10, 2025

04.10.25 -- Emerging Manufacturing Technologies For Cell Therapies

SPONSOR

Webinar: Inside the Development of an AAV8 Production Platform Designed for Scale

Adeno-associated virus (AAV) vectors are pivotal in gene therapy, yet their production faces significant challenges, including scalability, low recovery rates, and the need for effective separation of empty and full capsids. This webinar  presents a comprehensive AAV8 production platform developed together with CDMO Matica Biotechnology, and addresses industry pain points through innovative upstream and downstream processes. Click here to learn more.

FOCUS ON MANUFACTURING

Emerging Manufacturing Technologies For Cell Therapies

Cell & Gene Live explored the cutting-edge manufacturing technologies impacting cell therapy production. Our expert panel delved into innovative approaches such as automation solutions for increased efficiency, strategies for optimizing cell therapy delivery, and more.

LV And AAV Clarification With TFDF-Based Intensified Virus Production

Learn how Tangential Flow Depth Filtration (TFDF) enhances viral vector production, streamlining the clarification process and increasing efficiency and yield for LV and AAV manufacturing.

Making MSCs GMP: A Compliant Workflow

Generate GMP-compliant mesenchymal stem cells (MSCs) at scale with a closed, automated workflow. Learn how to optimize MSC harvest yields and ensure trilineage differentiation.

Sterility Testing: Isolator Solutions To Minimize Contamination Risk

Sterility testing is susceptible to contamination, resulting in costly false positives, batch failures, and production delays. Isolator technology offers a robust solution to mitigate these challenges.

Non-Viral Gene Modification For Ex-vivo Cell Therapy

Understand the advantages of non-viral transfection technologies for CRISPR- or transposon-based genetic modification cell and gene therapy.

Minimizing Cleanroom Contamination Risks In Drug Manufacturing

Considering ergonomics is crucial for optimizing cleaning efficiency and minimizing contamination risks. Explore key ergonomic considerations in cleanroom cleaning, best practices, and more.

Why Single-Use? Single-Use Technology In Pharmaceutical Manufacturing

Learn about the role of single-use technology in advanced therapy manufacturing, why pharmaceutical manufacturers are switching to disposable technology, and more.

Continuous Monitoring And Control Of Glucose And Lactate

This experiment demonstrates that continuous real-time monitoring of glucose and lactate and dynamic glucose feed control to a low-level set-point leads to improved process and product parameters.

Bioprocessing And Scale Up Of HEK293 Cells For AAV Production

Address your concerns with traditional viral vector production processes by using a scalable upstream AAV production platform solution for viral gene therapies.

SPONSOR

A Full-Service Solution Partner Disrupting the Outsourcing Paradigm

inSeption Group offers a full-service solution designed to disrupt the current outsourcing paradigm, resurrecting a common-sense approach to rebuild business trust and confidence in a client’s selected vendor. Primarily focused on oncology, hematology, neurodegenerative disorders, and rare/orphan disease indications, with a specialization in cell and gene therapy, inSeption has been a solution for its’ clients who have experienced the progressive degradation of today’s outsourcing options. Contact them.

MANUFACTURING SOLUTIONS

Vericheck ddPCR Empty-Full Capsid Kit - Bio-Rad Laboratories, Inc.

Revolutionizing Pharmaceutical Purification: Advanced Compound Processing - Sartorius

NB-KUL DF Cryopreservation Medium - Nucleus Biologics

The Future Of mRNA Manufacturing - Cytiva

Elutriation: How It Works - Invetech

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