Electroporation Enables Efficient Antibody Discovery By Mammalian Display

Developers of therapeutic antibodies are continually exploring advanced strategies to identify strong candidates and eliminate problematic ones early in the discovery process, optimizing resource use for the most viable leads.

Mammalian display offers a robust approach to pinpoint antibodies with optimal antigen affinity and favorable biophysical traits, critical for predicting developability.

Efficiently screening large libraries while maintaining high sequence diversity is essential for success. In a pilot study, researchers assessed two electroporation methods within a mammalian display workflow. MaxCyte electroporation outperformed the alternative method, delivering improved sequence diversity, broader library coverage, and a more efficient workflow.