Development Of An Efficient Manufacturing Process For Adenovirus

Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics. These challenges mostly arise from the size and complexity of the virus. Here, we present purification results of a process developed for the manufacturing of a recombinant adenovirus. This two-column process results in an adenovirus preparation comparable to clinical grade products, with high yield and very low host cell protein (HCP) and DNA contamination. It is readily scalable, simple, rapid, and efficient and thus well-suited for the production of clinical grade viral vectors.

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