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| Building an AAV8 Platform, Together: Lessons From a Collaborative Development Journey | Developing a scalable, GMP-ready AAV8 production platform is complex and requires a unified approach across upstream and downstream operations, data-driven decisions, and efficient progression from bench scale to manufacturing-relevant volumes. In this white paper, Matica Biotechnology and Sartorius demonstrate how collaboration enabled the design, optimization, and scale-up of an integrated AAV8 process to 50L with reproducible performance, sharing practical lessons in upstream optimization, downstream purification, capsid separation, and analytics to support flexible gene therapy manufacturing. |
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By Narinder Bhalla and José Manuel Otero, Ph.D., Lexeo Therapeutics | As the field matures, the most transformative gene therapies in heart health are treating delivery not as an afterthought but as a fundamental principle. | |
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| Twist Of Two: 2D-LC For Oligos | Article | KNAUER | Discover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples. |
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| A Quick Start Guide For Efficient Filtration | Manual | Cytiva | Learn how to properly install a TFF system with step-by-step guidance on component setup, calibration, and best practices to ensure optimal performance and reliable operation. |
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| Virus Reduction And Impurity Removal | Application Note | Bio-Rad Laboratories, Inc. | Examine a DOE-based study that reveals how buffer conditions impact virus and impurity clearance using a mixed-mode resin, as well as gain practical guidance for optimizing downstream purification. |
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| Overcoming Challenges In CGT Development | Webinar | CPC | Explore connector solutions for sterility, chemical compatibility, and ultra-low temperature challenges when setting up a therapeutic process for long-term success. |
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