Clarification Performance Of The UFMini®: Analyzing The Bio-Separation Of Chinese Hamster Ovary-S (CHO-S) Cells

Biomanufacturers are looking for ways to optimize their clarification processing efficiency. A user-friendly single-use centrifugation process that maintains cell viability and produces a highly clarified effluent could play a large role in helping to reduce the burden on downstream processes.

Evaluate the performance of CARR Biosystems’® UFMini single-use centrifuge in the clarification of CHO-S cells by measuring supernatant turbidity and starting/ ending cell viability. Cell harvest is a critical processing step in the production of monoclonal antibodies and other biologic products. This centrifuge successfully purified and concentrated the CHO-S cell feed while exhibiting low shear stress with minimal impact to cell viability.