Chromatography Single-Use Systems
ÄKTA™ single-use chromatography systems are designed where speed and flexibility are needed. Single-use flow kits eliminate the need for system cleaning and validation, reduce downtime and minimize risk for cross-contamination between product/batches. All systems are controlled by UNICORN™ software, a common control platform and user interface for all scales of operation.
For standard chromatography systems from Cytiva, visit this page.
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ÄKTA ready™ 450 is a single-use liquid chromatography system designed for small-scale manufacturing in GMP-regulated environments. The single-use flow path minimizes the need for cleaning and cleaning validation, allowing for quick changeover between productions and reducing the risk of carryover. |
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ÄKTA ready™ chromatography system SCS ÄKTA ready™ chromatography system has been redesigned as the SCS (standard configuration system) platform to meet current and future needs for batch manufacturing and intensified processing. The system retains the benefits of single-use processing, with one-piece disposable flow paths that allow quick changeover and reduce the risk of carryover, while eliminating the need for cleaning between runs. The system is designed to improve usability for operators of all skill levels and to remove friction in your manufacturing process. The flow range is from 1 to 600 L/h using 1/4 and 3/8 inch flow kits. |
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The ÄKTA ready™ chromatography system XL is a liquid chromatography system designed with a wide operating range to cover the manufacturing capacity needed from clinical to commercial scale. To meet the capacity demands from single-use upstream processes (2000 L high-titer feeds), the system operates large-scale columns (up to 1200 mm), using two flow kit sizes that cover a broad range of flow rates from 45 to 3500 L/h. |
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UNICORN control software offers real-time control of protein purification unit operations (column packing, chromatography and filtration) from laboratory bench, through development, to full-scale production. UNICORN control system meets the needs of full-scale production with manufacturing systems, while maintaining the flexibility needed for method and process development with the range of systems in the ÄKTA family. Version 8 is required for the new ÄKTA ready SCS model. The other ÄKTA ready systems are compatible with version 7 or version 8. |
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ÄKTA ready and ÄKTA ready™ extended These models of ÄKTA ready chromatography system will be replaced in 2027 by the SCS model above. Cytiva will continue to support existing systems for 10 years. ÄKTA ready (isocratic or gradient) configuration is suited for mAbs and recombinant protein purification. ÄKTA ready variable UV system has a three-wavelength monitor that is essential for monitoring the separation of, for example, full and empty AAV capsids, and nucleic acids such as plasmids and mRNA. ÄKTA ready™ extended system is designed with extra features to provide more flexibility in bioprocessing. It includes an integrated human-machine interface (HMI), additional sensors and valves, and capability to monitor and control Xcellerex™ XDUO mixers. |
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