Calypso Composition-Gradient Stop-Flow System

• K_d from pM to mM
• Reaction times from seconds to hours
• Self- and hetero-associations
• Interfaces with DAWN, miniDAWN and Optilab instruments for automated MALS and concentration measurements.

CG-MALS (composition-gradient multi-angle light scattering) is a label-free, immobilization-free technique for characterizing:

• Protein-protein interactions
• Protein-DNA complexes
• Other macromolecular interactions

CG-MALS characterizes biomolecular interactions from first principles by measuring the change in the weight-average molar mass (M_w) of a solution as a function of concentration and composition.