An Overview Of RNA Delivery: Challenges And Innovation

By Claire Gueguen Ph.D., Malik Hellal Ph.D., Maria Nicla Loviglio Ph.D., Patrick Erbacher Ph.D., and Alengo Nyamay’antu, Ph.D.

RNA has, historically, played a crucial role in revealing the genetic foundations and intricacies of various biological mechanisms. Over the past thirty years, its potential as a therapeutic modality has been increasingly acknowledged, with early successes demonstrating its viability. Nonetheless, delivering RNA effectively poses challenges. A variety of approaches have been developed for both in vitro and in vivo applications. While lipid-based solutions have been utilized in approved products, ongoing issues remain regarding their specificity and stability, which continue to be a key area of research.