AI-Designed Logic Circuits For Smarter Cancer Targeting

During this segment of Cell & Gene Live, "Building Smarter Cell Therapies with AI and Synthetic Biology," Senti Biosciences' Tim Lu, M.D., Ph.D. described how an AI-guided workflow at Senti optimized paired activating and inhibitory CAR designs to better distinguish cancer from healthy cells, outperforming manual engineering and accelerating lead selection. Claire Aldridge, Ph.D., emphasized treating AI as a practical technology to expand and refine design space, not as a replacement for wet labs.