A Power Number Model-Based Approach For Scalable Impeller Designs To Meet Oxygenation Demands Of Intensified Bioprocesses

By Sualyneth Galarza, Samantha Whitney, Marisa Maher, Jonathan Cain, Amy Mei, Amy Wood

Intensified bioprocesses are being developed to increase productivity and product yield while reducing facility footprint, production costs, and timelines for biologics manufacturing. The higher cell densities generated by intensification, create a challenge of sustaining oxygenation requirements through mixing and sparging activities while minimizing cell shear effects. To address current limitations, the bioreactor system design space must be expanded to deliver higher power densities to effectively support oxygenation demands while minimizing mixing times across all scales. The aim of this work was to use a power number model-based approach for the design of a scalable single-use impeller capable of reaching high power densities with low mixing time and tip speed.