A Case Study For Viral Vector Process Impurity Profile: Evaluation Of EndoCleave

Endonucleases are essential for ensuring the purity of viral vectors. By reducing host cell and plasmid DNA impurities, these enzymes improve product safety and meet regulatory standards. As the demand for AAV and LVV-based gene therapies increases, selecting the right endonuclease is critical for enhancing process efficiency and scalability.

This webinar, led by Dr. Soodeh Baghaee-Ravari of Genezen, explores the performance of a new DNA endonuclease, EndoCleave. Dr. Baghaee-Ravari will present findings from a comprehensive study that compares the enzyme's effectiveness against other commercially available options for both AAV and LVV production. Watch below to gain a deeper understanding of how critical process parameters, such as enzyme concentration, temperature, and salt concentration, impact nuclease clearance and overall product quality.