ARTICLES BY ERIN HARRIS
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In Vivo CAR T Needs More Than Better Cell Engineering8/26/2026
In vivo CAR T’s potential to expand access and simplify manufacturing hinges on targeted LNP delivery and solving the durability challenge.
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Reimagining Solid Tumor Immunotherapy With SRC-3-Edited Tregs8/20/2026
CoRegen’s investigational autologous cell therapy, CRG-150, is designed to disrupt tumor-driven immune suppression by knocking out SRC-3 in Tregs, potentially exposing solid tumors to the patient’s own immune response without lymphodepletion.
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Building Antigen-Specific Immune Tolerance For Autoimmune Disease8/10/2026
Antigen-specific immune tolerance could redefine autoimmune disease treatment by precisely retraining the immune system rather than broadly suppressing it.
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Solving Vector Yield Challenges Starts Long Before Manufacturing7/22/2026
Cell & Gene Live panelists take a deep dive into why solving vector yield challenges begins with early biological and manufacturing decisions rather than process optimization alone.
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Full FDA Approval For TECELRA Marks More Than A Regulatory Win For Solid Tumors7/17/2026
US WorldMeds' expanded FDA approval for TECELRA represents another important step forward for engineered cell therapies in solid tumors.
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FDA Approval Of TREGZI Signals A New Era For Precision Engineered Cell Therapy7/9/2026
Following the FDA approval of TREGZI, Orca Bio's precision engineered allogeneic cell therapy is redefining stem cell transplantation through improved immune control, advanced manufacturing, and a platform designed to expand the future of cell therapy.
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How CGT Developers Should Think About Manufacturing Models, Hybrid Strategies, And Scale6/29/2026
Our latest Cell & Gene Live examined how CGT developers can choose manufacturing models that support long-term commercial success by aligning biology, operations, supply chain, and scalability from the earliest stages of development.
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In Vivo Gene Editing Is Moving From Promise To Proof6/15/2026
CGT is shifting from technical promise to clinical execution as in vivo approaches reach an inflection point where delivery, durability, specificity, and manufacturability will determine whether the field can turn breakthrough science into safe, scalable, repeatable therapies.
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Driving Gene Therapy Beyond Rare Disease Will Define The Next Era Of CGT6/2/2026
Gene therapy’s next test is not proving it works, but proving it can scale.
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CGT Manufacturing Shifts From Capacity To Strategy5/21/2026
As manufacturing overcapacity reshapes the CGT landscape, success now depends less on access to capacity and more on strategic alignment across development, regulatory readiness, and long-term commercialization.