INSIGHTS ON CELL & GENE THERAPY DISCOVERY

• Potent Immune Response With Vernal’s LNP-mRNAs

  As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

• How mRNA Technology Engineers Next-Generation Antibodies

  Monoclonal antibodies (mAbs) stand as pivotal drug products and biochemical reagents in the 21st century. Explore how mRNA-encoded antigens could revolutionize antibody discovery.

• Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis

  Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.

• Effects Of mRNA Capping Technologies

  This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

• Methods for mRNA Poly(A) Sizing

  This study used Oxford Nanopore Technologies' Direct RNA Sequencing Kit and obtained successful sizing of poly(A) tail regions. The results are presented in a histogram and table format.

• Assessing Doggybone DNA For In Vitro Transcription

  In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.

• Evaluating CAR T-Cell Therapy Vascular Recruitment, Trafficking, And Killing

  Learn about a more human-relevant platform that enables researchers to assess the trafficking and killing efficiency of immunotherapy as well as the proof-of-concept of immuno-oncology co-therapy.

• Analytical Considerations For mRNA-Based Therapies

  Uncover why leveraging strong scientific expertise and comprehensive testing techniques will be vital in expediting development and upholding the integrity of these life-saving treatments.

• Navigating Complex Testing For Viral Vector-Based Gene Therapies

  To ensure the success of gene therapy, learn why it is crucial to partner with a CRO that can navigate the challenges of viral vector development and testing.

• Biomolecular Characterization With Mass Photometry

  What is mass photometry and how is it used? Explore this powerful analytical technology that measures the mass of single particles in solution accurately and without labels.