Newsletter | September 22, 2022

09.22.22 -- Reducing Product Loss During Frozen Storage And Shipment
 

 

REDUCING PRODUCT LOSS DURING FROZEN STORAGE AND SHIPMENT

With 200,000+ RoSS® shells sold, Single Use Support has less than 0.001% reported cases of product loss. Applicable for cold chain management in biomanufacturing to protect, fill, freeze, store, and ship drug substance in scalable batch volumes from a few mL to hundreds of L.

  • Cost-efficient thanks to minimized product loss rate
  • Independent from any type and size of single-use bioprocess container
  • Hybrid for single-use bags, bottles, and vials
  • Process-independent through modular single-use technologies
Reducing Product Loss To Save Costs

The breaking of single-use bags during liquid transfer of biologics means loss of very valuable drug substances. In this case study a global biotechnology company experienced a product loss rate during cold chain management of up to 5%. Its goal was to reduce product loss toward 0%. 
Freedom To Choose Your Single-Use Bag

Some suppliers have introduced protective single-use shell solutions — with the downside that they are only compatible for their own single-use bags. In comparison, the vendor-agnostic protective RoSS® shell shows positive effects on compatibility, flexibility, and, thus, supply chain security for CDMOs.
Hybrid Protection For Bags, Bottles, And Vials

Each primary packaging requires suitable fluid management solutions. When single-use bags, bottles, and vials are used, the number of platform systems accumulate in the production facilities. Harmonized process solutions for different types of primary packaging in one, be it single-use bags, bottles, or vials, optimize cost-efficiency of single-use technologies while reducing product loss rates.
Process-Independent Biomanufacturing

Inflexibility and lack of compatibility with other platform systems have led to increased operational and capital expenditures and added complexity in the manufacturing process for CDMOs. This case study demonstrates how modular and vendor-agnostic end-to-end process solutions help save CAPEX, while increased process speed at different scales helps reduce OPEX.