Newsletter | August 19, 2020

08.19.20 -- Reduce Risk And Simplify Cell Therapy Freezing And Logistics

Standardizing The Vein-To-Vein Logistics Workflow Challenge To Reach More Patients

The supply chain and logistics for cell and gene therapies is especially critical to ensure the right patient gets the right treatment at the right time. Collaboration is the key to solving challenges such as data management and process variability, as stakeholders work toward a common goal — getting these life-saving treatments to the people who need them.

Key Considerations For Cryogenic Preservation And T-Cell Viability

Cryopreservation provides critical protection for cell therapies by minimizing genetic changes. But cooling too slowly or quickly risks diminishing cell viability upon thaw. This article discusses the importance of controlled-rate cryopreservation, illustrating how mammalian cells change when frozen, and describes concrete cryopreservation strategies.

A Modern Take On Cell Therapy Logistics

Patient centricity is critical to the cell therapy workflow, because if a patient’s cell therapy doesn’t get there at the right time and in good shape, nothing else matters. Shipments are put at risk if the manufacturing workflow is delayed, there is a transport holdup, or the clinical site is not able to receive or manage the shipper. 

Taking Digital Control Of Cell Therapy Logistics: An Advanced Therapy Treatment Center Network Case Study

Within the manufacturing workflow there are two critical logistics steps: 1) transport of the starting material to the manufacturing site, and 2) return of the finished product to the treatment center. This case study describes work to establish and test a cryogenic logistics pathway for an allogeneic advanced therapy medicinal product (ATMP).