Newsletter | June 21, 2022

06.21.22 -- Market Outlook for Cell and Gene Therapy

 
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Excerpts From A Round Table Discussion: Challenges And Opportunities In Gynecologic Cancer Research

Find out how recent approvals of targeted therapies have led to meaningful improvements in patient care and outcomes and have also stimulated research, particularly in combination trials.

Increasing mRNA Capabilities, Capacity

The growing mRNA vaccine market ― projected to reach $127.3 billion by 2027 ― is fueling high demand for mRNA, which has resulted in a critical need to address mRNA manufacturing bottlenecks.

A Shared Opportunity: The Future Of Cell And Gene Therapy
Find out why the commercialization of cell and gene therapies raises several complex conversations and questions for employers and payers.
How mRNA Technology Is Shaping The Future Of Medicine

Discover how mRNA technologies open the doors to a whole range of new gene therapies and the role of lipid nanoparticles (LNPs) in current and future developments.

How To Minimize Supply Chain Disruptions In Biopharma

Read how medical device, pharmaceutical, or single-use system manufacturers can manage short-term interruptions to the supply chain without shutting down production.

The Impact Of Facility Design On The Safety Of Viral Vectors

It is critical to vet not just the expertise available at a CDMO, but also the effectiveness of their facility design to reduce risk and meet scale-up needs.

Mitigating Inherent Risks In Global Sample Processing

This article discusses solutions to the risks inherent in global sample processing. Knowing these risks and how to mitigate them will enable the consistent processing of high-quality samples in support of global research protocols

Improvements Toward Standardizing Viral Vector Manufacturing And Producer Cell Line Development

The TRiP System allows suppression of transgene expression during upstream processes, resulting in enhanced vector yield and purity, simplifying downstream processes.

Manufacturing Of Viral Vectors For Gene Therapy

Viral vectors are essential for delivering corrected genetic information to faulty genes within affected cells and are at the heart of the gene therapy process.

How Controlled Freezing Becomes Reality

Controlling the freezing behavior of bulk drug substance is the ultimate goal in biopharma manufacturing. This study demonstrates the impact of ice front growth speed on scalability of freezing protein solutions.

Allogeneic T-Cell Therapies: Efficient Commercial Manufacturing Readiness

A rationale-based methodology to address T-cell manufacturing challenges, based on the intended final manufacturing process, proposes a robust, scalable, cost-effective, and sustainable allogeneic platform.

Directly Link Phenotype To Gene Expression To Design Better Therapies

Understanding the genetic mechanisms of T cell polyfunctionality could be critical for developing effective therapeutics. The Opto Cell Therapy Development workflow makes it possible to identify these mechanisms by characterizing function at the single-cell level and linking phenotypic data to individual gene expression profiles.

EPCMV Pioneering In Pandemic Times

Utilize engineering, procurement, construction management, and validation (EPCMV) for rapid delivery of complex projects with tight deadlines and costs from start to finish on your life science capital projects.

Troubleshooting Automation: Find The Source Of Liquid Handling Errors

This troubleshooting guide will help you work through the critical issues and find the source of liquid handling error.

Lipid Nanoparticle Library For Non-Viral Delivery Of mRNA And saRNA Toward Vaccine And Cell & Gene Therapy Applications

Explore this proprietary ionizable lipid library, which has shown promising potency toward various applications involving cell therapy, protein replacement therapy, and RNA-based vaccines.

Best Practices In Viral Vector Analytical Characterization

Review tips and considerations for robust viral vector analytical characterization, including strategies to overcome challenges in assessing impurities and defining critical quality attributes (CQAs).

Increase The Productivity Of Your Lab

Did you know that you can increase the productivity and the efficiency of your laboratory by training your staff on how to fully leverage the capabilities of your analytical tools?

Moving The Needle: A Final Filling Case Study Webinar From Grand River Aseptic Manufacturing, Bausch+Ströbel, And Pall Corporation

Watch this webinar to learn about a collaboration that helped optimize a new filling line with single-use needles and reduced downtime.

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