How To Get The Most Out Of Your Cell Therapy Media Applications By The Addition Of Highly Pure L-Carnosine

Cell therapies based on mesenchymal stromal cells (MSCs) and T-cells (e.g. CAR-T cells) have become a commercial reality over the last decade, enabling a series of breakthroughs in patient care. Cell-based, engineered tissues are now poised to make significant contributions not only in the field of regenerative medicine, but also in the development of a more sustainable global food supply through the use of cultured meat.

These technologies all have in common a requirement for the efficient and reproducible cultivation of primary and stem cells. As cellular starting material is usually limited, it is essential that sufficient product be generated by maintaining high growth rates and maximizing the number of population doublings in bioreactors while keeping cells in the desired, physiological state. This can be especially challenging if cultivation must occur in well-defined, animal-origin-free and serum-free conditions. An increasing number of publications suggest that the addition of L-carnosine to cell culture media can be a powerful tool to achieve that goal.