Excerpts From A Round Table Discussion: Challenges And Opportunities In Gynecologic Cancer Research

By Rupa Doshi, Irene Figari and Mary Gunn

Gynecologic cancers are comprised of five major types: ovarian, uterine, cervical, vaginal, and vulvar. All women are at risk for these, and risk increases with age. Specific risk factors include a family history, human papillomavirus (HPV) infections (cervical cancer), genetic mutations such as BRCA1 and BRCA2 (ovarian cancer or OC), and hormone replacement therapy. Early screening, lifestyle choices, and knowledge of family cancer history can help play a role in the prevention of gynecologic cancers.

Globally, gynecologic cancers continue to be a major cause of morbidities and mortality. Significant unmet needs exist in the diagnosis and treatment of these cancers. Often, these tumors are detected in later stages when treatment options are limited, and advanced or recurrent disease is associated with a poor prognosis.