Newsletter | February 4, 2020

02.04.20 -- Dr. Bruce Levine's 7 Cell & Gene Trends To Watch In 2020


Good day Cell & Gene readers,


Bruce Levine, Ph.D., the Barbara and Edward Netter Professor in Cancer Gene Therapy at the University of Pennsylvania, president-elect of the International Society for Cell and Gene Therapy, and Cell & Gene Editorial Advisory Board member, details seven cell and gene therapy trends to watch in 2020.


By now, you’ve probably read the news that The Discovery Labs and Deerfield Management Company have formed The Center for Breakthrough Medicines — the CDMO they’ve referred to as the largest in the cell and gene therapy sector. To learn more about The Center for Breakthrough Medicines, I talked to Audrey Greenberg, executive managing director and board member of The Discovery Labs.


Erin Harris, editor in chief
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Industry Insights
Expanded Droplet Digital PCR (Polymerase Chain Reaction) Multiplexing Capability Using Two Different Strategies
Application Note | By Dianna Maar, Nicholas J. Heredia, and Shawn Hodges, Bio-Rad Laboratories, Inc.

Droplet Digital PCR (ddPCR) enables easy multiplexing of numerous targets within each fluorescent channel. Amplitude-based multiplexing achieves this by varying primer and/or probe concentrations. In probe-mixing multiplexing, probes are mixed at desired concentrations to place targets in a defined position on a 2D plot. This paper describes strategies for both approaches using the large portfolio of ddPCR assays readily available through Bio Rad.

First-In-Human Trials: A Make-Or-Break Milestone For Small Biopharmas
Article | Thermo Fisher Scientific

Whether biopharmaceutical companies have one candidate or 100, the directive is clear: moving quickly into first-in-human (FIH) testing is essential. But, how?

Tips For Viral Vector Production
Article | GE Healthcare Life Sciences

The viral vector market is highly active, and the interest in production technologies is driven by recent approvals in cell and gene therapy. Here, the challenges in viral vector manufacturing are shared so that a scalable and cost-efficient process suitable for GMP manufacturing environments can be obtained.

Confronting The Challenges Of Rare Disease
White Paper | United BioSource LLC (UBC)

This paper is intended as a discussion of the commonly encountered hurdles in studying rare diseases and how a cohesive and holistic approach can mitigate issues and help bring new treatments to patients.

Droplet Digital Polymerase Chain Reaction
White Paper | MilliporeSigma Cell and Gene

Leveraging the hyper accuracy of droplet digital PCR (ddPCR), viral and gene therapy developers gain additional confidence in titering assays and vector copy number determination.

Reducing Risks With Single-Sourced Modular Cleanrooms
E-Book | AES Clean Technology, Inc.

Life sciences industries require highly controlled environments for drug research development and manufacturing.

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