Case Study

Bioprocess Media Pooling Case Study

Source: Avantor
Avantor

Simplifying sampling with a closed system solution

Need

A biologic drug manufacturer was experiencing contamination issues due to an open media pooling process. The process required taking three 500mL media bottles into a biosafety cabinet, removing the caps, and open-transferring (pouring) media from the three bottles into one 2L bottle.

Solution

Avantor worked with the customer to determine the best solution for the application. A sterile, closed-system was designed by Avantor to help reduce contamination in the biologic drug manufacturer’s media pooling process.

Results

The customer realized process efficiency by removing the need for a biosafety cabinet, and the operator was able to open and manipulate the pre-sterilized assemblies in a more comfortable, ergonomic setting. The desired configuration was welded and ready for use in less than 15 minutes. Process throughput was increased by eliminating the need for assembling the tubing sets and autoclaving, which could take over an hour for the autoclave cycle alone. The frequency of contaminations was significantly reduced by implementing the closed system solution and eliminating the media open pooling process.

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