A SMART Platform For Scalable Biotherapeutic Development: cDNA To 200L Single Use Stirred Tank Bioreactor

Establishing a platform for developing and manufacturing therapeutic proteins will eliminate the bottleneck between cell line development and tech transfer. The Celltheon SMART^TM Technology Platform in combination with Pall Biotech’s manufacturing equipment accelerates time from cDNA to pilot scale with a pre-defined fed-batch and downstream processing platform for monoclonal antibodies and difficult to express therapeutic proteins In this case study, Celltheon demonstrates a workflow established to develop an RCB followed by scale-up and reproducible product quality from bench to pilot scale in the 200 L Allegro STR single-use bioreactor.